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Abstract 447: Has the expression of the Wnt-pathway in regard to cMYC and  -Catenin a predicitive influence on the kind of metastasis in colon cancer

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Download Abstract 447: Has the expression of the Wnt-pathway in regard to cMYC and  -Catenin a predicitive influence on the kind of metastasis in colon cancer
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  + Cancer Research cancerres.aacrjournals.org doi: 10.1158/1538-7445.AM2012-447 Cancer Res April 15, 2012 72; 447 Abstract 447: Has the expression of the Wnt-pathway in regard to cMYC and β-Catenin apredicitive influence on the kind of metastasisin colon cancer  Jens Strohäker  1 , Claudius Falch 2 , Claus Hann-von-Weyhern 3 , Patrick Adam 4 ,Alfred Königsrainer  2 , Falko Fend 4 , and Björn LDM Brücher  2  Author AffiliationsProceedings: AACR 103rd Annual Meeting 2012 ‐‐  Mar 31 ‐  Apr 4, 2012; Chicago, IL Abstract Background: cMYC as well as β-Catenin are downstream-targets of the Wnt-pathway and bothhave an important early function within the carcinogenesis and the progression of coloncancer. Additionally cMYC was found to be associated with a worse prognosis in other neoplasms. The goal of our investigations was the evaluation of the Wnt-pathway on primarynon-metastatic colon cancer compared to lymphatic, hepatic and peritoneal metastasis inregard to the expression of cMYC and β-Catenin. Methods: 98 patients with adenocarcinom of the colon and a postoperative pT2/3-status, who underwent surgical resection between 2006and 2008 at the University of Tübingen had been included within the study collective. 53patients had no metastasis (control group), while 45 patients revealed primary metastasis:lymphatic metastasis (n=20), hepatic spread (n=20) and multiple metastasize (n=5). cMYC andβ-Catenin was coloured on a Tissue-Micro-Array by immunohistochemistry with consecutivesemiquantitative analysis. Results: 17 of 98 patients (17%) had been positive for cMYC. 5 out of these 17 (29%) revelaed metastasis. 16 out of the 17 cMYC-positive patients showed a nuclear accumulation of β-Catenin (94%) (p=0.027). 40 out of 81 (49%) cMYC negative patientsrevealed metastasis. No significant correlation between nuclear positive cMYC and the rate or kind of metastasis was found (p=0.133). In 29 out of 81 cMYC-negative patients (36%) a strongexpression of β-Catenin was found. Conclusion: cMYC is well known for a worse prognosis incase of an overexpression in patients suffering from lymphoma. A correlation between theexpression of cMYC and the kind of metastasis and / or survival nor prognosis in patients withcolon cancer was not able to show (p=0.211). Additonally no correlation between the nuclear exprimed β-Catenin and different ways of metastasis was found (p=0.202). Citation Format:  {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd AnnualMeeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL.Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 447. doi:1538-7445.AM2012-447©2012 American Association for Cancer Research
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